|
Kidney Failure, Chronic
|
0.300 |
SusceptibilityMutation
|
disease |
RGD |
Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy.
|
29018182 |
2017 |
|
CORONARY ARTERY SPASM 1, SUSCEPTIBILITY TO
|
0.100 |
SusceptibilityMutation
|
phenotype |
CLINVAR |
|
|
|
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Therefore, this study aims to examine the relationship between the PIN1 and eNOS genes expression, as well as serum levels and hypertension in Alzheimer's disease sufferers.
|
28506742 |
2017 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Quantification of monocyte ecNOS mRNA and NO metabolites plasma levels from patients and controls (C) demonstrated NO system upregulation in patients notwithstanding the hypertension.
|
11112045 |
2000 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to determine whether Hhcy homocysteinylates endothelial nitric oxide synthase (eNOS) and alters caveolin-1 expression to decrease nitric oxide bioavailability, causing hypertension and renal dysfunction.
|
30778103 |
2019 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Given the vasodilatory role of the eNOS gene product, it is possible that the linkage recently reported for eNOS reflects its relationship with hypertension rather than preeclampsia.
|
10464002 |
1999 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
It was found that the myocardial infarction combined with hypertension group had a much higher serum ADMA level and relatively low levels of eNOS and NO compared to those of the other three groups; the myocardial infarction group and the hypertension group had a much higher serum ADMA level compared to that of the healthy control group and the two groups had much lower levels of eNOS and NO.
|
28337882 |
2017 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Also, EGb761 inhibited hypertension with hypercholesterolemia-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1β in the kidney tissues.
|
28915536 |
2017 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Reduced eNOS activity could mediate an increased stroke risk through hypertension or independent of hypertension through abnormal vasomotor responses, promoting atherogenesis, or increased platelet adhesion and aggregation.
|
9731617 |
1998 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Expression of eNOS is altered in many types of cardiovascular disease, such as atherosclerosis, diabetes and hypertension.
|
18692595 |
2009 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Also, treatment with EGb761 inhibited hypertension-induced decrease in endothelial nitric oxide synthase (eNOS) protein expression and increase in the protein expressions of inducible NO synthase (iNOS), TNF-α, IL-6 and IL-1B in the kidney tissues.
|
29351002 |
2018 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Hypertension in Gsn<sup>-/-</sup> mice was associated with reduced endothelial NO synthase (eNOS) mRNA expression and reduced eNOS protein trafficking to the plasma membrane.
|
29684438 |
2018 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
This study provides novel evidence that TNFα leads to endothelial dysfunction associated with hypertension and vascular remodeling in preeclampsia through down-regulation of endothelial nitric-oxide synthase (eNOS) by NF-κB-dependent biogenesis of microRNA (miR)-31-5p, which targets eNOS mRNA.
|
30279269 |
2018 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Evidence of interaction between the genetic loci of ADRB2 and NOS3 points to varied clinical, biochemical, and expression levels and a role in hypertension susceptibility.
|
25159081 |
2015 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Previous studies in adults have shown that chronic pulmonary hypertension is associated with decreased endothelial nitric oxide synthase (eNOS) expression in pulmonary arteries.
|
9727710 |
1998 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We also studied the expression of Sirt1, which regulates eNOS expression and Sirt3, which regulates SOD2 expression as possible epigenetic targets of enzyme expression involved in the long- term programming of hypertension.
|
30717220 |
2019 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
In conclusion, a high-sugar diet during STS increases the hypertension predisposition in adulthood to as high a level as LTS, and the mechanisms involved have similarities (participation of OS and eNOS and SOD expression) and differences (fatty acids and arachidonic acid only participate in LTS and an elevated level of endothelin-1 was only found in LTS) in both conditions.
|
29882756 |
2018 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Quantification of monocyte ecNOS mRNA and NO metabolites plasma level from patients and control subjects (C) demonstrated NO system up regulation in patients notwithstanding hypertension.
|
10809426 |
2000 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Diabetes or hypertension-mediated endothelial dysfunction show characteristics such as reduced nitric oxide synthesis through suppression of endothelial nitric oxide synthase activity in endothelial cells, reduced sensitivity of nitric oxide in smooth muscle cells, and inflammation - all of which have been either shown to be directly caused by gene regulatory mechanisms of non-coding RNAs or shown to be having a correlation with them.
|
30342074 |
2018 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We investigated the role of 7 variants of ACE, AGT and NOS3 and their correlation with NO(x) levels and ACE activity in hypertension susceptibility in 910 case-controls of both genders.
|
19379721 |
2009 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We investigated the association of these NOS3 tagSNPs and the haplotypes formed by them with hypertension and with nitrite levels in children and adolescents with obesity and with obesity plus hypertension.
|
24943287 |
2015 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
We conclude that, in contrast to our hypothesis, enhanced basal tone and agonist-induced vasoconstriction after neonatal CH is limited by increased NO-dependent pulmonary vasodilation resulting from greater eNOS expression and phosphorylation at activation residue Ser<sup>1177</sup><b>NEW & NOTEWORTHY</b> This research is the first to demonstrate enhanced nitric oxide-dependent vasodilation that limits increased vasoconstrictor reactivity in neonatal pulmonary hypertension.
|
28733445 |
2017 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
NOx and eNOS levels were significantly lower in the hypertension group compared to the control group (p < 0.001, both).
|
26114349 |
2015 |
|
Fetal Growth Retardation
|
0.690 |
AlteredExpression
|
phenotype |
BEFREE |
Elevated expression of ecNOS was found to be coupled with significantly lower SOD activity and glutathione level, and increased lipid peroxidation in IUGR neonates.
|
19779107 |
2009 |
|
Fetal Growth Retardation
|
0.690 |
AlteredExpression
|
phenotype |
BEFREE |
Our results indicated that IUGR reduced vasodilation via acetylcholine in aorta rings, decreased NO levels, and increased eNOS phosphorylation at Thr495.
|
28689502 |
2017 |